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Ambrisentan  (Plumonext)

Ambrisentan (Plumonext)

Manufacturer : MSN Laboratories | Active substance : Ambrisentan | Alternative Search : Plumonext | Prescription : Not Required

Plumonext tablet is the medicine used to treat pulmonary arterial hypertension (PAH).

Ambrisentan (Plumonext) 10mg

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Ambrisentan (Plumonext) 5mg

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60 Pills

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30 Pills

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Method of Usage

What is Ambrisentan (Plumonext)?

Plumonext tablet is the medicine used to treat pulmonary arterial hypertension (PAH). Pulmonary arterial hypertension is a condition of high pressure in the blood vessels carrying blood from the heart to the lungs. 

This condition affects the blood vessels in the lungs and develops when the blood pressure in the lungs is higher than usual.

It makes the hard work harder than usual to pump blood into the lungs. As a result, it damages the heart and causes symptoms such as chest pain and shortness of breath.

This issue can develop on its own or even be caused by other diseases or conditions. Depending on the condition, many solutions and treatments for PAH are available.

One of the primary drugs used to treat PAH effectively is Plumonext. This antihypertensive medicine contains ambrisentan as the active ingredient, which belongs to the class of endothelin receptor blockers.  

It blocks the natural chemical substance that effectively narrows the blood vessels in the lungs. As a result, the blood pressure will become stable. 

It also helps to enhance your quality of life by improving your condition and delaying the disease progression. 

How does Ambrisentan (Plumonext) work?

Plumonext is an ambrisentan generic tablet that acts as an endothelin receptor blocker. It blocks the action of endothelin, the natural substance, causing blood vessels to constrict. 

The narrowing of blood vessels maximizes the pressure in the lungs' blood vessels. It puts a person at risk. 

This antihypertensive tablet relaxes these blood vessels and maximizes the blood supply to the lungs. 

In other words, pulmonary arterial hypertension can cause tiredness, shortness of breath, chest pain, swelling of the legs and dizziness. 

Taking Plumonext tablets helps relax those blood vessels and lowers the blood pressure in the arteries of your lungs. 

As a result, you can carry out your regular activities efficiently and effectively. It also makes you feel less tired. 

Now, you understand your query clearly - what is ambrisentan used for? Scroll down to learn more details about this medication. 

How to use Ambrisentan (Plumonext)?

It is always essential to read the label of the ambrisentan 5 mg medicine before taking it. You can consume the tablet with or without food.

Without the doctor's recommendation, do not take this medicine on an empty stomach. 

The dosage of the drug is decided based on your medical condition, your body's response to treatment and the medications you are currently taking.

Swallow the tablet whole with a glass of water. Do not break, cut or chew the medicine.

Continue taking this tablet regularly at a fixed time and suggested duration for the best results.

If you have any doubt about usage or dosage, immediately ask the doctor or pharmacist. 

Take a medicine according to the doctor's suggested limit. Increasing the dosage may cause unwanted troubles. 

  • Missed dose

If you missed any ambrisentan 10 mg tablet dose, try to take it immediately when you remember or skip the missed dose when it is time for another dose.

Never take a double dose to compensate for the missed one, it’ll give severe side effects. 

  • Overdose

Taking this medication as per the doctor's directed dosage is always recommended. Never increase or decrease the dose on your own.

If you have taken too much of this medicine or facing symptoms like dizziness, headache, vomiting and nausea, immediately contact the doctor. 


Precautions and warnings

Pregnant women should not consume this medicine because it is unsafe during pregnancy. It may put the unborn child's life at risk.

If you are a woman of childbearing age, it is necessary to discuss with your doctor about the significance of birth control methods. 

Inform the doctor if you become pregnant or breastfeeding while consuming this tablet.

So, do not drive the vehicle or do anything that needs mental focus and attention until you witness how your body reacts to the medicine.

Go through the ingredients present because the drug may contain certain inactive ingredients that cause allergic reactions or other issues.

Inform your medical condition and history of your doctor, especially if you have a kidney or liver disorder. 

Talk to your doctor if your feet and hands are swelling because of fluid retention, liver problems and anaemia. 

When you observe symptoms such as fever, vomiting, nausea, stomach ache or dark-coloured urine, reach the doctor quickly because it could be a sign of liver problems. 

It is recommended to consult with doctor for children below 18 years.

If you have severe kidney disease, you must take this medication with caution.

Never increase or decrease dosage and do not stop the medicine without doctor’s advice.

Avoid taking this tablet if allergic to the medication's active ingredients and other substances. 

Seek medical attention if you notice symptoms like itching, swelling, skin rash, breathing difficulty and dizziness. 

If you have idiopathic pulmonary fibrosis, you must avoid this medication as it may further worsen your condition. 

Cost and Availability

Plumonext is available at Sanford Pharmacy and may be covered by insurance plans. Patients are advised to check with their insurance provider for coverage details and copay information. Generic versions of Ambrisentan may also be available, offering a more affordable option for some patients.

Side effects of Ambrisentan (Plumonext)

Most ambrisentan generic do not need medication attention and go away when your body adjusts to the medicine but if it continues, consult a doctor.

Here are the common side effects of this medicine that people occasionally experience.

  • Flushing (Warmth sense in the trunk, neck, ears and face)
  • Peripheral edema
  • Sinus inflammation
  • Nasal congestion 
  • Tiredness
  • Headache
  • Dizziness
  • Irregular heartbeat
  • Nausea


It is suggested to store the tablet at room temperature and keep it away from children, light and moisture.

Discard this drug properly when it has expired or is no longer needed.


Taking ambrisentan 10 mg with medicines such as Warfarin, Phenindione, Acenocoumarol, and Ciclosporin can change the effect of the tablet or cause specific undesirable side effects. 

Combining Plumonext with other medicines like Leflunomide, Lomitapide, Deferasirox, and Tizanidine may put your life at risk and even cause serious side effects.

So, it is better to consult the doctor about the medications you take to treat PAH beforehand to avoid a life-threatening situation.

If you take any other medicines, supplements or herbals, tell your doctor to avoid the possible interaction. The physician will analyze your health and suggest the proper direction to use Plumonext.

The tablet may cause fluid retention and swelling in the lower legs and hands. So, take it with caution, especially if you have heart issues such as heart failure.

Although the tablet's interaction with alcohol is unknown, it is advisable to speak with the doctor before consumption.

Ambrisentan (Plumonext) represents a valuable therapeutic option for individuals with pulmonary arterial hypertension. Its efficacy in improving exercise capacity, delaying disease progression, and enhancing quality of life underscores its importance in the management of PAH. At Sanford Pharmacy, we are dedicated to empowering patients with access to innovative treatments and comprehensive support services.

Frequently asked questions about Ambrisentan (Plumonext) (FAQs)

  1. How long does it take for Plumonext to work?

Consume Plumonext as a tablet once a day for the recommended duration. The medicine does not work immediately because it takes a week to a month to notice any improvement in symptoms.

  1. When should I consume Ambrisentan?

It is recommended to take the tablet with or without food once daily, whether morning or night.

But, take the medicine at around the same time regularly to witness the optimal result. Follow the directions mentioned on the prescription label carefully.

  1. How much does Ambrisentan (Plumonext) cost?

The ambrisentan cost is usually affordable and fits everyone's budget, but you can get it at a discounted price from Sanford online pharmacy. 

  1. Can I stop taking Ambrisentan?

Taking this tablet precisely as directed by the doctor is essential. Please do not take it more often or stop the medicine immediately without a doctor's advice.

  1. Is Plumonext a habit-forming drug?
No! The habit-forming tendency of the drug is extremely low, so you do not worry about anything unnecessarily.  But, follow the dosage and duration of the drug according to the doctor’s direction.

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